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p53 was overexpressed in 42.9% of the cases, and only 28.6% were positive for ER and PR. The current report provides 10- and 15-year rates of tumor control in the breast, as well as disease-free and overall survival rates following BCS and RT in a cohort of patients with Paget disease presenting without a palpable mass or mammographic density. A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Cancer. Our patient is disease-free, eight years after treatment by modified radical mastectomy and adjuvant irradiation. With a mean follow-up of 32 months (range, 4-109 months), there has been only 1 recurrence (7%), which was treated successfully by modified radical mastectomy. Diagnostic The indications for breast conservation surgery can be safely extended to include patients with breast cancers that involve the NAC. Maladie de Paget du mamelon : un cancer rare du seinSommaire Conclusions: Although some patients with Paget's disease might be well treated by breast conservation therapy, many patients have underlying multifocal carcinoma (including invasive cancer), which can be inapparent by examination and mammography. Between 1987 and 1998, 61 eligible patients were registered in the European Organization for Research and Treatment of Cancer Study 10873.
Ten patients had subareolar cancers that directly involved the nipple or areola; 5 patients had Paget disease of the nipple. Cosmetic results are satisfactory to excellent, as judged by both the patients and the surgeons.
2002;95:1-7.Paget´s disease of the nipple-areola complex: a plea for conservatismEusebio RB, Deckers PJ. Our observations confirm that Paget's cells are of glandular origin.Six cases of Paget's disease of the nipple without clinical or mammographic evidence of a breast mass are described, two without underlying carcinoma of duct origin, and four with very limited duct carcinoma in situ of the most distal lactiferous ducts.
In this communication we describe 11 cases of unilateral mammary Paget's disease, in which an unequivocal cytodiagnosis was made from nipple scrapings. All 37 women with a palpable mass had a pathological mammogram, 36 of them had carcinoma with an invasive component, 35 (95%) a cancer at a distance from the nipple, 31 (84%) a multifocal carcinoma. All 11 patients with Paget's disease and an associated lump proved to have invasive ductal carcinoma; five also had associated positive axillary nodes. Archival tumor tissues from 14 patients diagnosed between 1990 and 1999 with Paget disease of the breast were analyzed for these molecular markers by using an automated immunohistochemical assay. The majority of patients (97%) presented without an associated palpable mass. The treatment of choice is shown to be radical or modified radical mastectomy with adjuvant radiotherapy. An underlying carcinoma was found in 60 cases (98.4%), atypical epithelial hyperplasia in one. All 11 cases were subsequently proven histologically to be Paget's disease. Average tumor size was 1.6 cm (range, 0.2-3.5 cm). In five of these cases an underlying ductal carcinoma of the breast was simultaneously diagnosed by fine needle aspiration (FNA) cytology of a palpable breast lump. A change in sensation of the nipple-areola, such as itching and burning, is a common presenting symptom. Definitive treatment consisted of modified radical mastectomy in 32 patients, radiotherapy only in 2, and one patient had no definitive treatment. To date, no proof exists of the value of hormone receptors assays and routine adjuvant hormone therapy is not practiced.Six cases of Paget's disease of the nipple without clinical or mammographic evidence of a breast mass are described, two without underlying carcinoma of duct origin, and four with very limited duct carcinoma in situ of the most distal lactiferous ducts. Two additional patients had a recurrence in the breast as a component of first failure. The purpose of the current study was to assess the outcome of breast-conserving therapy by means of a cone excision and radiotherapy in patients with Paget disease of the nipple without associated invasive breast carcinoma.METHODS
The results of this study indicate that the c-erbB-2 oncoprotein may play a role in the pathogenesis of extramammary Paget's disease. In women with metastasis in an axillary lymphnode consistent with breast cancer and without aprimary tumor, MRI of the breast should beadded to clinical examination and mammography before definingit as an occult primary and planning therapy.Interest of the mammogram in Paget's disease of the breast, especially for a therapeutic decision in otherwise asymptomatic women with Paget's disease, who would be candidates for conservative treatment. Through a collaborative review of patients treated with BCS and RT from seven institutions, 38 cases of Paget disease of the breast presenting without a palpable mass or mammographic density were identified. Nipple-areolar complex resection for central subareolar cancers that directly involve the NAC, as well as for Paget disease of the nipple, extends the indications for breast conservation in other areas of the breast, and with acceptable cosmesis.Sanfujinka no jissai.
Ninety-seven percent of patients also received a boost to the remaining nipple or tumor bed, a median total dose of 61.5 Gy (range, 50.4-70 Gy). La mammographie est-elle utile dans la maladie de Paget du sein? Community teaching hospital. Fifteen patients, aged 46 to 88 years, whose central breast cancers involved the NAC precluding preservation of the NAC. The case is of interest in that Paget's disease occurred 21 months after presentation of an infiltrating cancer in the same breast which was treated by conservative surgery reserving the nipple and thus the opportunity for Paget's disease to occur. 1982;50:2203-5.Join ResearchGate to find the people and research you need to help your work.SUMMARY : Four fractures of the base of the coracoïd process were diagnosed and treated in a period of two years . Paget´s disease of the skin: a unifying concept of histo-genesis.